Hypocalcemia After the Administration of Denosumab in a Patient With Osteoporotic Fracture and Vitamin D Deficiency
نویسندگان
چکیده
Denosumab is a potent antiresorptive agent used for the treatment of osteoporosis and prevention skeletal-related events in patients with multiple myeloma or bone metastasis from solid tumors. Although denosumab generally seems to be safe well tolerated, denosumab-associated hypocalcemia may occur, majority cases are asymptomatic mild. Underlying malignancy, renal failure, calcium vitamin D deficiency, high turnover have been reported as risk factors hypocalcemia. Here, author reports case hypophosphatemia following administration osteoporotic fracture patient underlying but unrecognized severe deficiency. Following supplementation calcium, D, phosphorus, serum phosphorus levels returned normal after about 2 weeks. To avoid hypocalcemia, status, function should assessed corrected if appropriate. J Endocrinol Metab. 2022;12(3):111-115 doi: https://doi.org/10.14740/jem810
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ژورنال
عنوان ژورنال: Journal of Endocrinology and Metabolism
سال: 2022
ISSN: ['1923-2861', '1923-287X']
DOI: https://doi.org/10.14740/jem810